Panthers skipper Matt Moylan has been called up to the NSW Origin side after playmaker Adam Reynolds was ruled out of Game Three with a shoulder injury.
Moylan initially missed out on selection as NSW coach Laurie Daley opted for Wests Tigers custodian James Tedesco at fullback.
However Reynolds was unable to train on Wednesday morning and was subsequently released from the squad, gifting Moylan another opportunity to impress at Origin level.
The call-up leaves Panthers coach Anthony Griffin with a big decision to make regarding his final side to face the Sharks at Pepper Stadium on Sunday.
English recruit Zak Hardaker made a name for himself playing fullback for Leeds Rhinos, while Dallin Watene-Zelezniak and Will Smith have both previously filled in at the back for the Panthers.