The Panthers recorded a 32-22 victory over the Sea Eagles in front of over 20,000 fans at BlueBet Stadium.
Brian To'o showed no sign of Origin fatigue, scoring a hat-trick and making over 250 running metres.
Daine Laurie (344 run metres), Sunia Turuva (229 run metres) and Liam Henry (30 tackles and 0 missed) stepped up in the absence of key players out with injury.
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