The Panthers stormed back to winning ways with a resounding 40-12 win over Sydney Roosters at Allianz Stadium on Saturday.
A record-breaking Nathan Cleary led the Panthers to victory, as a 14-point haul saw him surpass Ryan Girdler as the greatest point scorer in Panthers history.
Paul Alamoti scored twice to put the Panthers ahead at half-time, with Cleary converting both to break the club's point-scoring record.
Isaiah Papali'i and Blaize Talagi each crossed for their first try in Penrith colours to put the Panthers in a commanding position, before Dylan Edwards and Casey McLean capped off a fantastic win.
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Highlights: Panthers v Roosters
A slow Panthers start saw the Roosters open the scoring through Daniel Tupou and take a 6-0 lead they held for much of the first half.
Led by Cleary's kicking and control, the Panthers fought their way back into the contest and ended up taking a 12-6 lead before half-time.
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Alamoti opens the Panthers account
Paul Alamoti scored two near-identical tries in the 23rd and 39th minute, finishing off a pair of backline moves orchestrated by Cleary and Edwards.
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Deja vu as Alamoti scores double
Cleary converted both tries to reach 1,573 career points, overtaking Ryan Girdler's record as the Panthers greatest point scorer of all time.
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Nathan Cleary becomes all-time top point scorer
A penalty goal early in the second half extended the lead, before Isaiah Papali'i pounced on a Mitch Kenny grubber to score his first Penrith try and put the Panthers ahead 20-6.
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Papali'i opens Panthers account
The Roosters pulled one back as Robert Toia scored from a clever scrum play, but the Panthers finished with a wet sail and coasted to victory.
An improvised Isaah Yeo grubber led to young half Blaize Talagi scoring his first try for the Panthers, putting Penrith on the cusp of victory.
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Talagi scores first Panthers try
The Panthers best try of the night came in the 66th minute when a quick shift and silky Scott Sorensen flick pass sent Dylan Edwards over for a spectacular, and well-deserved, four-pointer.
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Panthers purr with sensational try
Casey McLean capped off the Panthers night when he carved through the Roosters right edge, as Cleary ended the night with seven conversions from seven attempts.
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Casey McLean caps off the night
The Panthers broke the 40-point barrier on the stroke of full-time when Paul Alamoti landed a long-range penalty goal, rounding out a sweet victory for Penrith.
The Panthers return to CommBank Stadium in ANZAC Round, facing Manly Sea Eagles on Saturday 26 April.